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Obese non-insulin dependent diabetes mellitus (NIDDM) patients who do not respond to dietary control and who have a moderately elevated glycosylated haemoglobin levels with normal kidney functions.
Primary or secondary sulfonylurea failures. In these cases, metformin can be used alone or in combination with sulfonylureas, depending on the response to such treatment before considering transfer to insulin therapy.
Very unstable juvenile or maturity onset diabetes where a combination of insulin and metformin is beneficial.
Overweight NIDDM patients who will benefit with weight control by the use of metformin along with insulin therapy.
